Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, inhibition of the renal renin-angiotensin II-aldosterone system with angiotensin-converting enzyme inhibitor, angiotensin II type 1 receptor blocker or selective aldosterone inhibitor indirectly suppresses NADPH oxidase reducing renal ROS, proteinuria and glomerulosclerosis.
|
17665974 |
2007 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study clearly provided in vivo evidence for the AngII-independent MAPK activation by human (pro)renin receptor and induction of glomerulosclerosis with increased TGF-beta1 expression.
|
17494887 |
2007 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
In treatment studies, steroids prevented glomerulosclerosis in the anti-GBM model in contrast to angiotensin II inhibition, which lacked a protective effect, and urinary podocyte and TGF-β1 mRNA markers more accurately reflected both the amount of podocyte depletion and the degree of glomerulosclerosis compared with proteinuria under both scenarios.
|
28419296 |
2017 |
Glomerulosclerosis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Captopril significantly improved albuminuria and glomerulosclerosis in db/db mice, and these effects might be attributed to the down-regulation of angiotensin II expression and the expression of its down-stream profibrotic factors in the kidney, like connective tissue growth factor and vascular endothelial growth factor.
|
28130181 |
2017 |
Glomerulosclerosis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, ACE2 generates angiotensin 1-7, which may protect the kidney by attenuating the effects of angiotensin II, since deletion of the Ace2 gene leads to glomerulosclerosis in mice, and pharmacologic inhibition of ACE2 exacerbates experimental diabetic nephropathy.
|
19034303 |
2008 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis.
|
30005635 |
2018 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of the renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in transgenic hypertensive mice carrying both human renin and angiotensinogen genes.
|
9582107 |
1998 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis.
|
28202497 |
2017 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The deletion of the angiotensin-converting enzyme 2 gene in mice leads to worsening of angiotensin II-induced hypertension and has also been shown to cause glomerulosclerosis in aging male mice.
|
18408475 |
2008 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-resistant fructose-fed rats showed heavy proteinuria and glomerulosclerosis involving angiotensin II-dependent changes in renal gelatinases and inhibitors.
|
10922970 |
2000 |
Glomerulosclerosis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to low-protein diets and drugs that suppress angiotensin II activity, a variety of other agents and measures may have potential for impeding the process of glomerulosclerosis.
|
16828231 |
2006 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the relation of tissue-localized angiotensin II (Ang II) concentration with cardiac hypertrophy and glomerulosclerosis in Tsukuba hypertensive mice (THM) carrying both human renin and angiotensinogen genes.
|
9886895 |
1998 |
Glomerulosclerosis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant role of the increase in renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in double transgenic tsukuba hypertensive mice carrying both human renin and angiotensinogen genes.
|
9607405 |
1998 |